In this study, the morphological characteristics of P. albicans ATCC 10231 isolates from a health food market were investigated. P. albicans is the major human fungal pathogen of the genus Candida. Most isolates of P. albicans are yeast cells that form a single layer of large, basal hyphae that emerge from a thick aerial mycelium. The hyphae elongate by repeated rounds of tip extension and retraction. This study reports that morphological characteristics of P. albicans are useful as a tool for identification of P. albicans strains. The health food market exhibited 10 out of 20 isolates were identified as P. albicans by morphological characteristics (Fig. 1) and the phenotypic characteristics of these isolates were further investigated. In order to evaluate their susceptibility to antifungal drugs, 10 isolates of P. albicans were tested against fluconazole, amphotericin B and flucytosine. The isolates were highly resistant to all three antifungal agents tested. The pathogenicity of these isolates to healthy mice was also investigated using a murine model. The mortality induced by P. albicans isolates was lower than C. albicans ATCC 10231. This result shows that P. albicans has a low pathogenicity to mice. The morphological characteristics of P. albicans are useful as a tool for identification of P. albicans strains and for evaluation of their pathogenicity.
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